The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Histone H2AX promotes DNA double-strand break (DSB) repair and immunoglobulin heavy
chain (IgH) class switch recombination (CSR) in B-lymphocytes. CSR requires activation-…

The Saccharomyces cerevisiae chromatin silencing factor Sir2 suppresses genomic instability
and extends replicative life span. In contrast, we find that mouse embryonic fibroblasts (…

The design of underground coal mines requires a clear understanding of the overburden
response, the loading of pillars, the loading of the gob, the pillar failure process, and the …

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Artemis are classical
nonhomologous DNA end-joining (C-NHEJ) factors required for joining a subset of DNA …

Over the last decade, EEG resting-state microstate analysis has evolved from a niche
existence to a widely used and well-accepted methodology. The rapidly increasing body of …

p53-binding protein 1 (53BP1) participates in the cellular response to DNA double-stranded
breaks where it associates with various DNA repair/cell cycle factors including the H2AX …

Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage
lymphomas with recurrent chromosome 14 translocations involving the T cell receptor α/δ (…

The sudden collapse of approximately 3 Ha of room-and-pillar workings at a limestone mine
in southwestern Pennsylvania in 2015 resulted in an air blast that injured three mine …

In this paper, the advantage of using numerical models with the strength reduction method (SRM)
to evaluate entry stability in complex multiple-seam conditions is demonstrated. A coal …