Identification of a by-product of nitric oxide synthase activity in human acute brain injury with in vivo proton magnetic resonance spectroscopy

M Silberstein, D Lane, S Dodd… - American journal of …, 2002 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Laboratory studies have been used to identify nitric oxide
as a notable mediator in neuronal death after acute brain injury. To our knowledge, this has …

[HTML][HTML] The role of the nitric oxide pathway in brain injury and its treatment—from bench to bedside

PS Garry, M Ezra, MJ Rowland, J Westbrook… - Experimental …, 2015 - Elsevier
Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

Fluorometric assay of nitrite and nitrate in brain tissue after traumatic brain injury and cerebral ischemia

AM Rao, A Dogan, JF Hatcher, RJ Dempsey - Brain research, 1998 - Elsevier
Nitric oxide synthase (NOS) is distributed within the brain, and nitric oxide (NO) is felt to be
involved in the pathophysiology of deterioration after head injury and cerebral ischemia …

Traumatic brain injury

R Vink, TK McIntosh - Magnetic Resonance Spectroscopy and Imaging in …, 1996 - Springer
Traumatic injury to the central nervous system continues to be the major cause of mortality
and morbidity in children and young adults. While much has been accomplished on a …

Electron paramagnetic resonance study on nitric oxide production during brain focal ischemia and reperfusion in the rat

S Sato, T Tominaga, T Ohnishi, ST Ohnishi - Brain research, 1994 - Elsevier
The production of nitric oxide (NO) during brain focal ischemia and reperfusion was using
diethyldithiocarbamate (DETC)/Fe-citrate, NO trapping reagents, and electron paramagnetic …

Effects of oxygen and glucose deprivation on the expression and distribution of neuronal and inducible nitric oxide synthases and on protein nitration in rat cerebral …

D Alonso, J Serrano, I Rodríguez… - Journal of …, 2002 - Wiley Online Library
Abstract Changes in the nitric oxide (NO) system of the rat cerebral cortex were investigated
by immunohistochemistry, immunoblotting, NO synthase (NOS) activity assay, and magnetic …

Brain nitrite production during global ischemia and reperfusion: an in vivo microdialysis study

M Shibata, N Araki, J Hamada, T Sasaki, K Shimazu… - Brain Research, 1996 - Elsevier
Nitric oxide (NO) is considered to be associated with the pathogenesis of cerebral ischemic
injury. In the present study, NO production was continuously monitored employing in vivo …

Neuronal nitric oxide synthase activation and peroxynitrite formation in ischemic stroke linked to neural damage

MJL Eliasson, Z Huang, RJ Ferrante… - Journal of …, 1999 - Soc Neuroscience
Nitric oxide (NO) is a new intercellular messenger that occurs naturally in the brain without
causing overt toxicity. Yet, NO has been implicated as a mediator of cell death in cell death …

Electron paramagnetic resonance (EPR) detection of nitric oxide produced during forebrain ischemia of the rat

T Tominaga, S Sato, T Ohnishi… - Journal of Cerebral …, 1994 - journals.sagepub.com
To detect if nitric oxide (NO) is produced in rat forebrain ischemia, we applied an electron
paramagnetic resonance (EPR) NO-trapping technique. We also performed a detailed …

Magnetic resonance spectroscopy

R Vink - Head injury. Chapman & Hall, London, 1997 - api.taylorfrancis.com
Traumatic brain injury continues to be the major cause of death in individuals under 44
years of age (see Chapter 1). In addition to the high degree of mortality, the morbidity …