Advances in stem cell biology have generated intense interest in the prospect of transplanting
stem cells into the nervous system for the treatment of neurodegenerative diseases. Here, …

Diseases of the nervous system have devastating effects and are widely distributed among
the population, being especially prevalent in the elderly. These diseases are often caused by …

OBJECTIVE: Anticoagulation-treated patients presenting with intracranial hemorrhage, including
subdural hematoma, epidural hematoma, subarachnoid hemorrhage, and intracerebral …

Objective The US Food and Drug Administration–approved trial, “A Phase 1, Open‐Label,
First‐in‐Human, Feasibility and Safety Study of Human Spinal Cord‐Derived Neural Stem …

Background We report the initial results from a phase I clinical trial for ALS. We transplanted
GMP-grade, fetal human neural stem cells from natural in utero death (hNSCs) into the …

Gene therapy for motor neuron diseases requires efficient gene delivery to motor neurons (MNs)
throughout the spinal cord and brainstem. The present study compared adeno-…

Gene therapy is, potentially, a powerful tool for treating neurodegenerative diseases such as
amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, Parkinson's disease (PD) and …

Objective: To test the safety of spinal cord transplantation of human stem cells in patients
with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to …

BACKGROUND: No United States-based clinical trials have attempted delivery of biological
therapies directly to the spinal cord for treatment of amyotrophic lateral sclerosis (ALS) …

A novel peptide with the binding characteristics of tetanus toxin was identified with phage
display, for application in therapeutic protein and vector motor and sensory neuron targeting. A …