This review of the mechanism of osteopetrosis incriminates molecular defects in osteoclasts
as the cause of the imbalance between bone formation by osteoblasts and bone resorption …

Background Osteopetrosis encompasses a group of rare metabolic bone diseases characterized
by impaired osteoclast activity or development, resulting in high bone mineral density. …

Osteopetrosis includes a group of inherited diseases in which inadequate bone resorption
is caused by osteoclast dysfunction. Although molecular defects have been described for …

In principle, transplantation of mesenchymal progenitor cells would attenuate or possibly
correct genetic disorders of bone, cartilage and muscle, but clinical support for this concept is …

We previously demonstrated that autologous natural killer (NK)–cell therapy after
hematopoietic cell transplantation (HCT) is safe but does not provide an antitumor effect. We …

The lysosome, an intracellular organelle responsible for the intracellular sorting, recycling,
and digestion of organic molecules, was first described 50 years ago by Christian de Duve. 1 …

The potential benefits of unrelated donor marrow transplantation are offset by the immunologic
complications of graft-versus-host disease (GVHD) and infection. Therefore, we used …

… Drawing on extensive archival and secondary materials, Phil Orchard examines the interplay
among governments, individuals, and international organizations that has shaped how …

… Arrows indicate the times of transplantation for patients (P). … Arrows indicate the times
of transplantation for patients (P). … Arrows indicate the times of transplantation for patients (P). …

Background In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function
of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and …