Brain tumors are the most common solid tumors in children. With the increasingly widespread
availability of MRI, the incidence of childhood brain tumors seemed to rise in the 1980s, …

Background Paediatric low-grade glioma is the most common CNS tumour of childhood.
Although overall survival is good, disease often recurs. No single universally accepted …

This study estimated the maximum tolerated dose (MTD) of imatinib with irradiation in children
with newly diagnosed brainstem gliomas, and those with recurrent malignant intracranial …

Background. Activation of the mitogen-activated protein kinase pathway is important for
growth of pediatric low-grade gliomas (LGGs). The aim of this study was to determine the …

Transient electrocardiographic changes and arrhythmias are known to be acute manifestations
of cardiotoxcity secondary to cancer therapy with anthracyclines or cardiac irradiation. …

Purpose We evaluated the feasibility of administering carboplatin as a radiosensitizer
during craniospinal radiation therapy (CSRT) to patients with high-risk medulloblastomas (MBs) …

Purpose Diffuse brainstem gliomas (BSGs) and other high-grade gliomas (HGGs) of childhood
carry a dismal prognosis despite current treatments, and new therapies are needed. …

Purpose Recent studies have demonstrated a high frequency of IDH mutations in adult “secondary”
malignant gliomas arising from preexisting lower grade lesions, often in young adults…

Background The prognosis for children with malignant glioma is poor. This study was
designed to determine whether lomustine and temozolomide following radiotherapy and …

Background Because definitive resection or radiotherapy for pediatric low‐grade gliomas (LGGs)
may be associated with severe and permanent adverse effects, medical management …