BACKGROUND AND PURPOSE: HD entails damage of the WM. Our aim was to explore in
vivo the regional volume and microstructure of the brain WM in HD and to correlate such …

ABSTRACT BACKGROUND AND PURPOSE Early white matter (WM) changes and cortical
atrophy in Huntington's disease (HD) are often evident before disease onset and extend …

Although much prior work has focused on the basal ganglia and cortical pathology that
defines Huntington's disease (HD), recent studies have also begun to characterize cerebral …

Objective To quantify 18-month changes in white matter microstructure in premanifest (pre-
HD) and symptomatic Huntington's disease (symp-HD). To investigate baseline clinical …

White matter (WM) degeneration is an important feature of Huntington's disease (HD)
neuropathology. To investigate WM degeneration we used Diffusion Tensor Imaging and …

The striatum, a subcortical structure, is the principal target of the neurodegenerative process
in Huntington's disease (HD). The measurement of striatal atrophy using the bicaudate ratio …

Objective To investigate structural connectivity and the relationship between axonal
microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and …

Background Huge advances have been made in understanding and addressing confounds
in diffusion MRI data to quantify white matter microstructure. However, there has been a lag …

Background and objectives: Regional cerebral atrophy occurs in carriers of the Huntington's
disease (HD) gene mutation before clinical diagnosis is possible. The current inability to …

Background: Huntington's disease is marked by progressive neuroanatomical changes,
assumed to underlie the development of the disease's characteristic symptoms. Previous …