Idiopathic pulmonary fibrosis is a fatal disorder that starts as an alveolitis and progresses to
interstitial fibrosis. Correlative morphologic, physiologic, and biochemical studies in 29 …

… Crystal, and the first trial with plasmid-liposome complexeswas carried out by G. J. Nabel. …
Crystal, unpublished observations. Through the cooperation of investigators, the FDA, and the …

… to our development of a therapy for α1 antitrypsin (AAT) deficiency, an autosomal recessive
disorder associated with a serum deficiency of AAT and development of emphysema (Crystal…

Direct transfer of the normal cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
gene to airway epitheiium was evaluated using a replicationdeficient recombinant …

The respiratory epithelium is a potential site for somatic gene therapy for the common
hereditary disorders α1-antitrypsin (α1AT) deficiency and cystic fibrosis. A replication-deficient …

… Crystal, RG Protocol for gene therapy of the respiratory manifestations of cystic fibrosls
using a replication deficient recombinant adenovirus to transfer the normal cystic fibrosis …

The role of bone marrow (BM)-derived precursor cells in tumor angiogenesis is not known.
We demonstrate here that tumor angiogenesis is associated with recruitment of …

Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate
and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-…

Idiopathic pulmonary fibrosis is a fibrotic lung disease characterized by an increased number
of mesenchymal cells in the alveolar walls. Alveolar macrophages constitutively express …

… S., Trapnell, BC, Curristin, SM, Cutting, GR & Crystal, RG Extensive post-transcriptional
deletion of the coding sequences for part of nucelotide-binding fold 1 in respiratory epithelial …