BACKGROUND AND PURPOSE: Patients with spontaneous intracerebral hemorrhage (ICH)
frequently have small areas of signal loss on gradient-echo T2*-weighted MR images, …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

The heterogeneity of common variable immunodeficiency (CVID) calls for a classification
addressing pathogenic mechanisms as well as clinical relevance. This European multicenter …

A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

The protein cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential negative regulator of
immune responses, and its loss causes fatal autoimmunity in mice. We studied a large family …

Inflammatory responses are associated with cardiovascular disease and may be associated
with dementing disease. We evaluated the long‐term prospective association between …

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies
have identified common CKD susceptibility variants. The CKDGen consortium performed …

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of
the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-…

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

TREX1 acts in concert with the SET complex in granzyme A–mediated apoptosis, and
mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus. Here, we …