PURPOSE: Mild cognitive impairment (MCI) is thought to be the prodromal phase to
Alzheimer's disease (AD). We analyzed patterns of gray matter (GM) loss to examine what …

Voxel-based morphometry (VBM) has already been applied to MRI scans of patients with
Alzheimer’s disease (AD). The results of these studies demonstrated atrophy of the …

BACKGROUND AND PURPOSE: The distribution of multiple sclerosis (MS) lesions in the
brain follows a specific pattern, with most lesions in the periventricular regions and in the deep …

Purpose: To prospectively investigate whether T1 changes in normal-appearing white
matter (WM) and normal-appearing gray matter (GM) in multiple sclerosis (MS) are global or …

BACKGROUND: Brain atrophy studies often use FSL-BET (Brain Extraction Tool) as the first
step of image processing. Default BET does not always give satisfactory results on 3DT1 MR …

Hypointense T1 lesions in multiple sclerosis patients correlate with axonal loss at autopsy
and biopsy. We evaluated the chemical substrate of hypointense T1 lesions by using in vivo …

PURPOSE.: To automatically segment multiple sclerosis (MS) lesions into three subtypes (ie,
enhancing lesions, T1 “black holes”, T2 hyperintense lesions). MATERIALS AND …

Background To measure hippocampal volume change in Alzheimer's disease (AD) or mild
cognitive impairment (MCI), expert manual delineation is often used because of its supposed …

To describe signal and contrast properties of an isotropic, single-slab 3D dataset [double
inversion-recovery (DIR), fluid-attenuated inversion recovery (FLAIR), T2, and T1-weighted …

Purpose To examine the benefits of using near-isotropic single-slab three-dimensional (3D)
magnetic resonance (MR) imaging for the creation of subtraction images and to evaluate …