In vivo detection of postictal perturbations of cerebral metabolism by use of proton MR spectroscopy: preliminary results in a canine model of prolonged generalized …

R Neppl, CM Nguyen, W Bowen… - American journal …, 2001 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Biochemical studies of seizures in patients and laboratory
animals have monitored postictal perturbations in cerebral metabolism with either invasive …

Proton MR spectroscopy in patients with seizure disorders.

SN Breiter, S Arroyo, VP Mathews… - American journal …, 1994 - Am Soc Neuroradiology
PURPOSE To evaluate the ability of proton MR spectroscopy to detect metabolic
abnormalities in the seizure focus of humans with epilepsy. METHODS Single-voxel MR …

The effect of epileptic seizures on proton MRS visible neurochemical concentrations

RJ Simister, MA McLean, TM Salmenpera, GJ Barker… - Epilepsy research, 2008 - Elsevier
PURPOSE: To investigate post-ictal changes in cerebral metabolites. METHODS: We
performed a longitudinal quantitative proton magnetic resonance spectroscopy (MRS) study …

Proton magnetic resonance spectroscopic imaging for discrimination of absence and complex partial seizures

F Cendes, JA Stanley, FO Dubeau… - Annals of Neurology …, 1997 - Wiley Online Library
We performed proton magnetic resonance spectroscopic imaging of the temporal lobes
between, during, and soon after nonconvulsive seizures in 20 patients with documented …

A short‐echo‐time proton magnetic resonance spectroscopic imaging study of temporal lobe epilepsy

RJ Simister, FG Woermann, MA McLean, PA Bartlett… - …, 2002 - Wiley Online Library
Purpose: We used short‐echo‐time proton magnetic resonance spectroscopy imaging
(MRSI) to study metabolite concentration variation through the temporal lobe in patients with …

Metabolite ratios to assumed stable creatine level may confound the quantification of proton brain MR spectroscopy

BSY Li, H Wang, O Gonen - Magnetic resonance imaging, 2003 - Elsevier
In localized brain proton MR spectroscopy (1H-MRS), metabolites' levels are often
expressed as ratios, rather than as absolute concentrations. Frequently, their denominator is …

Proton nuclear magnetic resonance spectroscopic imaging of human temporal lobe epilepsy at 4.1 T

H Hetherington, R Kuzniecky, J Pan… - Annals of …, 1995 - Wiley Online Library
We performed proton magnetic resonance spectroscopic imaging (MRSI) at high magnetic
field (4.1 T) to study N‐acetylaspartate, creatine, and choline levels in the brains of normal …

In vivo quantitation of metabolite concentrations in the brain by means of proton MRS

O Henriksen - NMR in Biomedicine, 1995 - Wiley Online Library
MRS offers unique possibilities for non‐invasive studies of biochemistry in the human brain
in vivo. A growing body of evidence suggests that proton MRS may contribute to the clinical …

Partial volume effects in volume localized phased‐array proton spectroscopy of the temporal lobe

WL Strauss, JS Tsuruda… - Journal of Magnetic …, 1995 - Wiley Online Library
MRS techniques can aide in confirming the location of seizure foci in temporal lobe epilepsy.
N‐acetyl aspartate (NAA). creatine plus phosphocreatine. choline‐containing compounds …

Neuron loss localizes human temporal lobe epilepsy by in vivo proton magnetic resonance spectroscopic imaging

JW Hugg, KD Laxer, GB Matson… - Annals of Neurology …, 1993 - Wiley Online Library
Temporal lobe epileptogenic foci were blindly localized in 8 patients with medically
refractory unilateral complex partial seizures using noninvasive in vivo proton magnetic …