… However, the major factor(s) controlling S1PR1 expression in B cells remains to be
identified. In this regard, it is notable that although S1PR1 expression is compromised in KLF2-…

The egress of lymphocytes from the thymus and secondary lymphoid organs into circulatory
fluids is essential for normal immune function. The discovery that a small-molecule inhibitor …

Background Stroke thrombolysis with alteplase is currently recommended 0–4·5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Background The effects of the dose of dialysis and the level of flux of the dialyzer membrane
on mortality and morbidity among patients undergoing maintenance hemodialysis are …

Background In patients with end-stage renal disease, anemia develops as a result of
erythropoietin deficiency, and recombinant human erythropoietin (epoetin) is prescribed to correct …

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to
siblings of probands. Replication has been inconsistent for reports of significant genetic …

Background Malignant infarction of the middle cerebral artery (MCA) is associated with an
80% mortality rate. Non-randomised studies have suggested that decompressive surgery …

Background and Purpose—Animal research and clinical studies in head trauma patients
suggest that moderate hypothermia may improve outcome by attenuating the deleterious …

Background: Although the clinical features of space-occupying ischemic stroke are well
known, there are limited prospective data on the clinical course of complete middle cerebral …