… In KRAS-driven cancer cells, aspartate addition can rescue S-phase arrest induced by
glutamine deprivation, indicating its critical role in both purine and pyrimidine nucleotide …

Microglia constitute the primary resident immune surveillance cell in the brain and are thought
to play a significant role in the pathogenesis of several neurodegenerative disorders, such …

Advances in our understanding of the biological basis and molecular characteristics of
ependymal tumors since the latest iteration of the World Health Organization (WHO) classification …

… Furthermore, we show that Akt’s effects on histone acetylation are mediated through the
metabolic enzyme ATP-citrate lyase and that pAkt(Ser473) levels correlate significantly with …

Conventional methods for intraoperative histopathologic diagnosis are labour- and time-intensive,
and may delay decision-making during brain-tumour surgery. Stimulated Raman …

Somatic mutations in isocitrate dehydrogenase 1 or 2 (IDH1/2) contribute to the pathogenesis
of cancer via production of the "oncometabolite" D-2-hydroxyglutarate (D-2HG). Elevated D…

Several types of pediatric cancers reportedly contain high-frequency missense mutations in
histone H3, yet the underlying oncogenic mechanism remains poorly characterized. Here we …

… Asparagine’s ability to directly suppress apoptosis in metabolically compromised cells may
… , as our data suggest that a cell’s sensitivity to apoptosis upon asparagine depletion is …

The de novo synthesis of the nonessential amino acid serine is often upregulated in cancer.
In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine …

Glucose and glutamine are the two principal nutrients that cancer cells use to proliferate and
survive. Many cancers show altered glucose metabolism, which constitutes the basis for in …