Objective: To assess whether the level of multiple sclerosis (MS) -related disability in the
Olmsted County population has changed over a decade, and to evaluate how the rate of initial …

In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …

The purpose of this study was to use serial imaging to gain insight into the sequence of
pathologic events in Alzheimer's disease, and the clinical features associated with this sequence. …

Background Cortical disease has emerged as a critical aspect of the pathogenesis of multiple
sclerosis, being associated with disease progression and cognitive impairment. Most …

Objective: To correlate different methods of measuring rates of brain atrophy from serial MRI
with corresponding clinical change in normal elderly subjects, patients with mild cognitive …

… In general, the aMCI determination is made when the memory measures fall –1.0 to –1.5 SD
below the means for age and education appropriate individuals in our community. Rigid cut-…

… 1-SD increase 1.7, p < 0.001) and greater whole brain APC (hazard ratio for a 1-SD increase
1.4… Both ventricular APC (hazard ratio for a 1-SD increase 1.59, p = 0.001) and whole brain …

Objective An extensive analysis of white matter plaques in a large sample of multiple sclerosis
(MS) autopsies provides insights into the dynamic nature of MS pathology. Methods One …

Objective To analyze the clinical findings, response to therapy, outcome, and incidence of
primary central nervous system vasculitis (PCNSV) in a large cohort from a single center …

Mild cognitive impairment (MCI), particularly the amnestic subtype (aMCI), is considered as
a transitional stage between normal aging and a diagnosis of clinically probable Alzheimer's …