Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing
ST Fitzgerald, Y Liu, D Dai… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot
analogs for in vitro endovascular device testing using animal blood of various species …
analogs for in vitro endovascular device testing using animal blood of various species …
Novel methodology to replicate clot analogs with diverse composition in acute ischemic stroke
S Duffy, M Farrell, K McArdle, J Thornton… - Journal of …, 2017 - jnis.bmj.com
Background Translational research on clot composition may be advanced by the use of clot
analogs for the preclinical evaluation of mechanical thrombectomy devices. This work …
analogs for the preclinical evaluation of mechanical thrombectomy devices. This work …
Quantifying the mechanical and histological properties of thrombus analog made from human blood for the creation of synthetic thrombus for thrombectomy device …
W Merritt, AM Holter, S Beahm, C Gonzalez… - Journal of …, 2018 - jnis.bmj.com
Background Untreated ischemic stroke can lead to severe morbidity and death, and as such,
there are numerous endovascular blood-clot removal (thrombectomy) devices approved for …
there are numerous endovascular blood-clot removal (thrombectomy) devices approved for …
The impact of thromboemboli histology on the performance of a mechanical thrombectomy device
I Yuki, I Kan, HV Vinters, RH Kim… - American journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Recently we published a novel method of thrombus
preparation for use in a swine model for evaluation of thrombectomy designs. The clot (fibrin …
preparation for use in a swine model for evaluation of thrombectomy designs. The clot (fibrin …
Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment
S Johnson, J Chueh, MJ Gounis, R McCarthy… - Journal of …, 2020 - jnis.bmj.com
Background Clot mechanical properties are influenced by composition and the arrangement
of components within the clot. This work investigates the effects of platelet-driven contraction …
of components within the clot. This work investigates the effects of platelet-driven contraction …
Standardized fabrication method of human-derived emboli with histologic and mechanical quantification for stroke research
Background As access to patient emboli is limited, embolus analogs (EAs) have become
critical to the research of large vessel occlusion (LVO) stroke and the development of …
critical to the research of large vessel occlusion (LVO) stroke and the development of …
Artificial stroke clots: how wide is the gap to the real world?
M Berndt, S Prothmann, C Maegerlein, P Oberdieck… - World Neurosurgery, 2018 - Elsevier
Objective Especially since the establishment of mechanical thrombectomy as part of
standard stroke therapy, artificial thrombi have become important in the training of …
standard stroke therapy, artificial thrombi have become important in the training of …
Imaging clot characteristics in stroke and its possible implication on treatment
AS Luthman, L Bouchez, D Botta, MI Vargas… - Clinical …, 2020 - Springer
Ischemic cerebral stroke is an increasingly treatable entity due to the recent developments in
intravascular clot extraction, with recent research indicating that the efficacy of the chosen …
intravascular clot extraction, with recent research indicating that the efficacy of the chosen …
Per-pass analysis of thrombus composition in patients with acute ischemic stroke undergoing mechanical thrombectomy
S Duffy, R McCarthy, M Farrell, S Thomas, P Brennan… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—Mechanical thrombectomy may involve multiple attempts to
retrieve the occluding thrombus. This study examined the composition of thrombus …
retrieve the occluding thrombus. This study examined the composition of thrombus …
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from …
Background and purpose There is still much debate whether bridging-therapy [intravenous
thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to …
thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to …