Novel human acute ischemic stroke blood clot analogs for in vitro thrombectomy testing

ST Fitzgerald, Y Liu, D Dai… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Previous studies have successfully created blood clot
analogs for in vitro endovascular device testing using animal blood of various species …

Novel methodology to replicate clot analogs with diverse composition in acute ischemic stroke

S Duffy, M Farrell, K McArdle, J Thornton… - Journal of …, 2017 - jnis.bmj.com
Background Translational research on clot composition may be advanced by the use of clot
analogs for the preclinical evaluation of mechanical thrombectomy devices. This work …

Quantifying the mechanical and histological properties of thrombus analog made from human blood for the creation of synthetic thrombus for thrombectomy device …

W Merritt, AM Holter, S Beahm, C Gonzalez… - Journal of …, 2018 - jnis.bmj.com
Background Untreated ischemic stroke can lead to severe morbidity and death, and as such,
there are numerous endovascular blood-clot removal (thrombectomy) devices approved for …

The impact of thromboemboli histology on the performance of a mechanical thrombectomy device

I Yuki, I Kan, HV Vinters, RH Kim… - American journal …, 2012 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Recently we published a novel method of thrombus
preparation for use in a swine model for evaluation of thrombectomy designs. The clot (fibrin …

Mechanical behavior of in vitro blood clots and the implications for acute ischemic stroke treatment

S Johnson, J Chueh, MJ Gounis, R McCarthy… - Journal of …, 2020 - jnis.bmj.com
Background Clot mechanical properties are influenced by composition and the arrangement
of components within the clot. This work investigates the effects of platelet-driven contraction …

Standardized fabrication method of human-derived emboli with histologic and mechanical quantification for stroke research

Y Liu, AS Reddy, J Cockrum, MC Ajulufoh… - Journal of Stroke and …, 2020 - Elsevier
Background As access to patient emboli is limited, embolus analogs (EAs) have become
critical to the research of large vessel occlusion (LVO) stroke and the development of …

Artificial stroke clots: how wide is the gap to the real world?

M Berndt, S Prothmann, C Maegerlein, P Oberdieck… - World Neurosurgery, 2018 - Elsevier
Objective Especially since the establishment of mechanical thrombectomy as part of
standard stroke therapy, artificial thrombi have become important in the training of …

Imaging clot characteristics in stroke and its possible implication on treatment

AS Luthman, L Bouchez, D Botta, MI Vargas… - Clinical …, 2020 - Springer
Ischemic cerebral stroke is an increasingly treatable entity due to the recent developments in
intravascular clot extraction, with recent research indicating that the efficacy of the chosen …

Per-pass analysis of thrombus composition in patients with acute ischemic stroke undergoing mechanical thrombectomy

S Duffy, R McCarthy, M Farrell, S Thomas, P Brennan… - Stroke, 2019 - Am Heart Assoc
Background and Purpose—Mechanical thrombectomy may involve multiple attempts to
retrieve the occluding thrombus. This study examined the composition of thrombus …

Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from …

R Rossi, S Molina, OM Mereuta, A Douglas… - Journal of …, 2022 - Springer
Background and purpose There is still much debate whether bridging-therapy [intravenous
thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to …