Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
SJ Arnold, EJ Robertson - Nature reviews Molecular cell biology, 2009 - nature.com
Genetic studies have identified the key signalling pathways and developmentally regulated
transcription factors that govern cell lineage allocation and axis patterning in the early …
transcription factors that govern cell lineage allocation and axis patterning in the early …
The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
SJ Arnold, GJ Huang, AFP Cheung, T Era… - Genes & …, 2008 - genesdev.cshlp.org
The embryonic subventricular zone (SVZ) is a critical site for generating cortical projection
neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are …
neurons; however, molecular mechanisms regulating neurogenesis specifically in the SVZ are …
[PDF][PDF] Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages
Innate lymphoid cells (ILCs) are a recently recognized group of lymphocytes that have
important functions in protecting epithelial barriers against infections and in maintaining organ …
important functions in protecting epithelial barriers against infections and in maintaining organ …
Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
SJ Arnold, UK Hofmann, EK Bikoff, EJ Robertson - 2008 - journals.biologists.com
The T-box transcription factor eomesodermin (Eomes) has been implicated as an important
component in germ layer induction and patterning in vertebrate embryos. In the mouse, …
component in germ layer induction and patterning in vertebrate embryos. In the mouse, …
[HTML][HTML] Brachyury is a target gene of the Wnt/β-catenin signaling pathway
SJ Arnold, J Stappert, A Bauer, A Kispert… - Mechanisms of …, 2000 - Elsevier
To identify target genes of the Wnt/β-catenin signaling pathway in early mouse embryonic
development we have established a co-culture system consisting of NIH3T3 fibroblasts …
development we have established a co-culture system consisting of NIH3T3 fibroblasts …
E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation
β-catenin is a multifunctional protein found in three cell compartments: the plasma membrane,
the cytoplasm and the nucleus. The cell has developed elaborate ways of regulating the …
the cytoplasm and the nucleus. The cell has developed elaborate ways of regulating the …
[HTML][HTML] Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice
…, T Wiech, F Grahammer, SJ Arnold… - The Journal of …, 2010 - Am Soc Clin Investig
Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The
postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and …
postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and …
Pluripotency factors regulate definitive endoderm specification through eomesodermin
Understanding the molecular mechanisms controlling early cell fate decisions in mammals
is a major objective toward the development of robust methods for the differentiation of …
is a major objective toward the development of robust methods for the differentiation of …
The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation
…, S Dräger, EK Bikoff, EJ Robertson, SJ Arnold - Nature cell …, 2011 - nature.com
Instructive programmes guiding cell-fate decisions in the developing mouse embryo are
controlled by a few so-termed master regulators. Genetic studies demonstrate that the T-box …
controlled by a few so-termed master regulators. Genetic studies demonstrate that the T-box …
[HTML][HTML] Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo
SJ Arnold, S Maretto, A Islam, EK Bikoff… - Developmental …, 2006 - Elsevier
Three closely related mammalian R-Smads, namely Smad1, Smad5 and Smad8, are
activated by BMP receptors. Here we have taken a genetic approach to further dissect their …
activated by BMP receptors. Here we have taken a genetic approach to further dissect their …