Microvascular integrity is lost during focal cerebral ischemia. The degradation of the basal
lamina and extracellular matrix are, in part, responsible for the loss of vascular integrity. Matrix …

Both vascular endothelial growth factor (VEGF) and integrin α v β 3 play roles in angiogenesis.
In noncerebral vascular systems, VEGF can induce endothelial integrin α v β 3 expression…

Background and Purpose—Platelets become activated and accumulate in brain microvessels
of the ischemic microvascular bed after experimental focal cerebral ischemia. The binding …

… of microvessels expressing t-PA at 2 hours and 7 days after MCAO in either the Ic or Ip
regions (Fig. 3), and no detectable t-PA in the Ic parenchyma at any time point. In contrast, t-PA …

… Takeo Abumiya … Takeo Abumiya … Statistical analyses were performed using two-way
analysis of variance or Student's t-test where appropriate. Significance was set at 2 P < 0.05. …

… Recently it has been revealed that the complex of T 3 and thyroid hormone receptor-β
elevates the L-PGDS promoter activity by binding to a thyroid hormone response element. …

Fluid shear stress is 1 of the major factors that control gene expression in vascular endothelial
cells. We investigated the role of shear stress in the regulation of the expression of fetal …

… T cells, 71 and decreased the ratio of regulatory T cells after the administration of an
immunologic adjuvant. Despite advances in genetic studies on RNF213 functions, a gene-targeting …

Background and Purpose High blood viscosity causes blood stagnation and subsequent
pathological thrombotic events, resulting in the development of ischemic stroke. We …

Vascular endothelial growth factor (VEGF) is a unique growth factor associated with angiogenesis,
vascular permeability, and neuroprotection. The aim of this study was to observe the …