Epithelial–mesenchymal transition in cancer development and its clinical significance

…, K Mimori, T Yokobori, H Ishi, T Beppu… - Cancer …, 2010 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) plays a critical role in embryonic development.
EMT is also involved in cancer progression and metastasis and it is probable that a …

Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function

M Yoshida, S Horinouchi, T Beppu - Bioessays, 1995 - Wiley Online Library
… and Beppu, T. (1987) Effects of trichostatins on differentiation of murine erythroleukemia …
and Beppu, T. (1990). Structural specificity for biological activity of trichostatin A, a specific …

[HTML][HTML] Management of thrombocytopenia due to liver cirrhosis: a review

H Hayashi, T Beppu, K Shirabe… - World journal of …, 2014 - ncbi.nlm.nih.gov
Thrombocytopenia is a common complication in liver disease and can adversely affect the
treatment of liver cirrhosis, limiting the ability to administer therapy and delaying planned …

[HTML][HTML] Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

M Yoshida, M Kijima, M Akita, T Beppu - Journal of Biological Chemistry, 1990 - Elsevier
… Reversible histone acetylation, which occurs in the t-amino group of specific internal lysine
residues located at the highly basic N-terminal domains of core histones, was discovered by …

Measurement of fractional anisotropy using diffusion tensor MRI in supratentorial astrocytic tumors

T Beppu, T Inoue, Y Shibata, A Kurose, H Arai… - Journal of neuro …, 2003 - Springer
In vivo, water diffusion displays directionality due to presence of complex microstructural
barriers in tissue. The extent of directionality of water diffusion can be expressed as a fractional …

[HTML][HTML] Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

…, M Yoshida, K Sugita, S Horinouchi, T Beppu - Journal of Biological …, 1993 - Elsevier
… The inhibitoryeffect was enhanced by the prolonged preincubation of the enzyme
preparation with trapoxina t 4 "Cand reached a plateau by 1 h (Fig. 3 B ) . Suchenhancement of …

Long‐term and perioperative outcomes of laparoscopic versus open liver resection for colorectal liver metastases with propensity score matching: a multi‐institutional …

T Beppu, G Wakabayashi, K Hasegawa… - Journal of Hepato …, 2015 - Wiley Online Library
Background The aim of the present study was to clarify the surgical outcome and long‐term
prognosis of laparoscopic liver resection (LLR) compared with conventional open liver …

Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker

…, Y Motomura, S Hosaka, T Beppu, T Ishiko… - Biochemical and …, 2003 - Elsevier
With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular
carcinoma (HCC) is rapidly increasing world wide. We identified glypican-3 (GPC3), a novel …

Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression.

…, M Nishikawa, S Horinouchi, T Beppu - Journal of Biological …, 1994 - ASBMB
The molecular action of leptomycin B (LMB), an agent inducing arrest of the eukaryotic cell
cycle at G1 and G2 phases, was investigated by analyzing an LMB resistance gene of …

Fractional anisotropy value by diffusion tensor magnetic resonance imaging as a predictor of cell density and proliferation activity of glioblastomas

T Beppu, T Inoue, Y Shibata, N Yamada, A Kurose… - Surgical neurology, 2005 - Elsevier
BACKGROUND: In vivo, water diffusion displays directionality due to presence of complex
microstructural barriers in tissue. The extent of directionality of water diffusion can be …