The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and
pathologic diagnosis of DLB incorporating new information about the core clinical features and …

Clinicopathologic correlation studies are critically important for the field of Alzheimer disease
(AD) research. Studies on human subjects with autopsy confirmation entail numerous …

Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer’s disease (AD) pathophysiology. While the detailed molecular mechanisms …

… A thioflavin-T fluorescence assay showed increased thioflavin-T signals in aliquots of α-synuclein
phosphorylated at Ser 129 (Fig. 5d), suggesting the formation of β-sheeted fibrils. In …

To learn about the carboxy-terminal extent of amyloid g-protein (Ag) composition of senile
plaques (SPs) in the brain affected with Alzheimer’s disease (AD), we employed two end-…

The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

Mutations in presenilin genes account for the majority of the cases of the familial form of
Alzheimer's disease (FAD). Presenilin is essential for γ-secretase activity, a proteolytic activity …

Background The accumulation of soluble and insoluble aggregated amyloid-beta (Aβ) may
initiate or potentiate pathologic processes in Alzheimer’s disease. Lecanemab, a humanized …

… Notably, T-positive neurofibrillary tangles and neuropil threads in some of these sections
were never labeled with the anti-synuclein antibodies in double-label confocal microscopy …

… amyloid (A ) in senile plaques, Helen Hsieh,1,3 Guy Seabrook,5 intraneuronal neurofibrillary
tangles, depressed brain David Borchelt,6 Takeshi Iwatsubo,4 function, and neuronal …