[HTML][HTML] Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
…, PV DiStefano, S Suutarinen, TR Kiehl… - … England Journal of …, 2018 - Mass Medical Soc
Background Sporadic arteriovenous malformations of the brain, which are morphologically
abnormal connections between arteries and veins in the brain vasculature, are a leading …
abnormal connections between arteries and veins in the brain vasculature, are a leading …
[HTML][HTML] CORTECON: a temporal transcriptome analysis of in vitro human cerebral cortex development from human embryonic stem cells
Many neurological and psychiatric disorders affect the cerebral cortex, and a clearer
understanding of the molecular processes underlying human corticogenesis will provide greater …
understanding of the molecular processes underlying human corticogenesis will provide greater …
[HTML][HTML] The explainability paradox: Challenges for xAI in digital pathology
The increasing prevalence of digitised workflows in diagnostic pathology opens the door to
life-saving applications of artificial intelligence (AI). Explainability is identified as a critical …
life-saving applications of artificial intelligence (AI). Explainability is identified as a critical …
Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience
Although telepathology (TP) has not been widely implemented for primary frozen section
diagnoses, interest in its use is growing as we move into an age of increasing sub-…
diagnoses, interest in its use is growing as we move into an age of increasing sub-…
Evolutionary algorithms+ domain knowledge= real-world evolutionary computation
…, R Subbu, N Eklund, TR Kiehl - IEEE Transactions on …, 2006 - ieeexplore.ieee.org
We discuss implicit and explicit knowledge representation mechanisms for evolutionary
algorithms (EAs). We also describe offline and online metaheuristics as examples of explicit …
algorithms (EAs). We also describe offline and online metaheuristics as examples of explicit …
Intracranial aneurysms: from vessel wall pathology to therapeutic approach
An aneurysm is a focal dilatation of an arterial blood vessel. Luminal forces, such as high
blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial …
blood flow, shear stress and turbulence, are implicated in the pathogenesis of intracranial …
[PDF][PDF] Nicotinamide ameliorates disease phenotypes in a human iPSC model of age-related macular degeneration
Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …
Hybrid simulation of cellular behavior
TR Kiehl, RM Mattheyses, MK Simmons - Bioinformatics, 2004 - academic.oup.com
Motivation: To be valuable to biological or biomedical research, in silico methods must be
scaled to complex pathways and large numbers of interacting molecular species. The correct …
scaled to complex pathways and large numbers of interacting molecular species. The correct …
Association between early-onset Parkinson disease and 22q11. 2 deletion syndrome: identification of a novel genetic form of Parkinson disease and its clinical …
… Author Contributions: Butcher and Kiehl contributed equally to this work. Bassett had full
access to all of the data in the study and takes responsibility for the integrity of the data and the …
access to all of the data in the study and takes responsibility for the integrity of the data and the …
Critical illness–associated cerebral microbleeds
Background and Purpose— Cerebral microbleeds (petechial hemorrhages) are a well-known
consequence of cerebral amyloid angiopathy and chronic hypertension among other …
consequence of cerebral amyloid angiopathy and chronic hypertension among other …
