User profiles for Takashi Ochi
 | Takashi OchiUniversity of Leeds Verified email at leeds.ac.uk Cited by 1248 |
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
XRCC4 and XLF are two structurally related proteins that function in DNA double-strand
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called …
break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF, also called …
Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions
XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two
essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that …
essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that …
[PDF][PDF] CCDC61/VFL3 is a paralog of SAS6 and promotes ciliary functions
Centrioles are cylindrical assemblies whose peripheral microtubule array displays a 9-fold
rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry …
rotational symmetry that is established by the scaffolding protein SAS6. Centriole symmetry …
[HTML][HTML] The spatial organization of non-homologous end joining: from bridging to end joining
Non-homologous end joining (NHEJ) repairs DNA double-strand breaks generated by DNA
damage and also those occurring in V(D)J recombination in immunoglobulin and T cell …
damage and also those occurring in V(D)J recombination in immunoglobulin and T cell …
Different DNA end configurations dictate which NHEJ components are most important for joining efficiency
…, G Watanabe, CA Gerodimos, T Ochi… - Journal of Biological …, 2016 - ASBMB
The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing
dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first …
dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first …
[PDF][PDF] Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair
T Ochi, X Gu, TL Blundell - Structure, 2013 - cell.com
Nonhomologous end joining (NHEJ) is central to the repair of double-stranded DNA breaks
throughout the cell cycle and plays roles in the development of the immune system. Although …
throughout the cell cycle and plays roles in the development of the immune system. Although …
Dissection of DNA double-strand-break repair using novel single-molecule forceps
Repairing DNA double-strand breaks (DSBs) by nonhomologous end joining (NHEJ) requires
multiple proteins to recognize and bind DNA ends, process them for compatibility, and …
multiple proteins to recognize and bind DNA ends, process them for compatibility, and …
Anti‐PDGF‐B monoclonal antibody reduces liver fibrosis development
S Ogawa, T Ochi, H Shimada, K Inagaki… - Hepatology …, 2010 - Wiley Online Library
Aim: To evaluate the usefulness of a platelet‐derived growth factor (PDGF)‐B specific
monoclonal antibody (mAb) as a therapeutic agent to treat chronic liver fibrosis. Methods: Liver …
monoclonal antibody (mAb) as a therapeutic agent to treat chronic liver fibrosis. Methods: Liver …
A hybrid system approach to the analysis and design of power grid dynamic performance
…, TJ Koo, H Ebina, T Yamazaki, T Ochi… - Proceedings of the …, 2011 - ieeexplore.ieee.org
In this paper, we describe an approach to the analysis and design of power grid dynamic
performance based on hybrid systems theory. Power grid is a large-scale cyber-physical …
performance based on hybrid systems theory. Power grid is a large-scale cyber-physical …
[PDF][PDF] Mutations in the NHEJ component XRCC4 cause primordial dwarfism
Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity.
Mutations in several components of the NHEJ pathway have been identified, often associated …
Mutations in several components of the NHEJ pathway have been identified, often associated …
