Background and Purpose Standard radiographic criteria for hematoma enlargement have not
been established. We undertook this investigation to assess the incidence and time course …

The Cognitive Abilities Screening Instrument (CASI) has a score range of 0 to 100 and provides
quantitative assessment on attention, concentration, orientation, short-term memory, long…

Background and Purpose—The effect of ebselen, a seleno-organic compound with antioxidant
activity through a glutathione peroxidase–like action, on the outcome of acute ischemic …

Background and Purpose— Based on previous studies comparing different recombinant tissue
plasminogen activator (rt-PA) doses, we performed a clinical trial with 0.6 mg/kg, which is …

Background The antiplatelet drug cilostazol is efficacious for prevention of stroke recurrence
compared with placebo. We designed the second Cilostazol Stroke Prevention Study (…

Cilostazol, an antiplatelet drug that increases the cyclic adenosine monophosphate (AMP)
levels in platelets via inhibition of cyclic AMP phosphodiesterase, has been used in chronic …

We studied the mechanism of hemorrhagic infarction after acute cerebral embolism in 160
patients by brain computed tomography and angiography. Hemorrhagic infarction during the …

Wider use of oral anticoagulants has led to an increasing frequency of warfarin-related
intracerebral hemorrhage (ICH). The high early mortality of approximately 50% has remained …

Background and Purpose— Although the efficacy of anticoagulant therapy for primary
prevention of stroke in patients with nonvalvular atrial fibrillation (NVAF) has been established, …

Background and Purpose—The optimal intensity of warfarin therapy for secondary prevention
of stroke in nonvalvular atrial fibrillation (NVAF) remains unclear. We studied the efficacy …