There is an abundance of evidence suggesting the involvement of altered levels of expression
of neurotrophic factors in the pathophysiology of neuropsychiatric disorders. Although …

Chromatin remodeling such as changes in histone acetylation has been suggested to play an
important role in the pathophysiology and treatment of mood disorders. In the present study…

The beneficial effect of physical activity (PA) on the brain has been well established. Both
acute and regular PA can boost a range of cognitive functions and enhance mood and mental …

Differential diagnosis is sometimes difficult in practical psychiatric settings, in terms of using
the current diagnostic system based on presenting symptoms and signs. The creation of a …

Abnormal emotional processing is involved in the pathophysiology of bipolar disorder (BD)
and major depressive disorder (MDD). However, whether the neural mechanism underlying …

BACKGROUND: Individuals with mood disorders exhibit altered function of the hypothalamic-pituitary-adrenal
(HPA) axis in response to stress. The glucocorticoid receptor (GR) plays …

According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia
(SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder …

Abundant evidence shows that various forms of physical exercise, even conducted briefly,
may improve cognitive functions. However, the effect of physical exercise on creative thinking …

It has been recently suggested that contact with nature improves mood via reducing the
activity of the prefrontal cortex. However, the specific regions within the prefrontal cortex that …

Glyoxalase-1 (Glo1) is an antioxidant enzyme which detoxifies α-ketoaldehydes to prevent
the accumulation of pro-oxidant compounds, such as methylglyoxal, in all cell types. Glo1 has …