The gastrointestinal tract (GIT) represents the largest interface between the human organism
and the external environment. In the lumen and upper part of the mucus layer, this organ …

It has become increasingly evident in recent years that the gut microbiome and the brain
communicate in a bidirectional manner, with each possibly affecting the other’s functions. …

The gut and brain link via various metabolic and signalling pathways, each with the potential
to influence mental, brain and cognitive health. Over the past decade, the involvement of …

Background—Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in
part by decreasing the availability of endothelial nitric oxide (NO). Although HMG CoA …

Hypoxia induces vasoconstriction, in part, by down-regulating endothelial cell nitric oxide
synthase (ecNOS) expression. Previous studies indicate that 3-hydroxy-3-methylglutaryl-…

Background. Despite widespread advocacy for shared decision making (SDM), the
empirical evidence regarding its effectiveness to improve patient outcomes has not been …

The paper proposes an approach that combines reliability analyses and multi-criteria decision
methods to optimize maintenance activities of complex systems. A failure mode, effects, …

Toll-like receptors (TLRs) are powerful molecular regulators by which the immune system
may “sense” the environment and protect the host from pathogens or endogenous threats. In …

Vitamin E is an important antioxidant that primarily protects cells from damage associated with
oxidative stress caused by free radicals. The brain is highly susceptible to oxidative stress, …

Failure Mode and Effects Analysis (FMEA) is a safety and reliability analysis tool widely used
for the identification of system/process potential failures, their causes and consequences. …