Phosphoinositide 3-kinases (PI 3-Ks) 1 are a subfamily of lipid kinases that catalyze the
addition of a phosphate molecule specifically to the 3-position of the inositol ring of …

Phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P 2 ), a key molecule in the phosphoinositide
signalling pathway, was thought to be synthesized exclusively by phosphorylation of …

Perhaps the most dominant theme that has emerged in the past decade of signal transduction
research is that proteins can become acutely targeted to new cellular locations (usually …

Aim This systematic article reviews the literature on the confounding parameters that affect
short implant survival in order to establish specific surgical and prosthetic protocols that …

Pleckstrin homology (PH) and phosphotyrosine binding (PTB) domains are structurally related
regulatory modules that are present in a variety of proteins involved in signal transduction, …

Src homology 2 (SHZ) domains on the regulatory subunit of phosphoinositide 3-kinase (PI 3-kinase)
mediate its binding to specific tyrosine-phosphorylated proteins in stimulated cells. …

It has been demonstrated that the lipid products of the phosphoinositide 3-kinase (PI3K) can
associate with the Src homology 2 (SH2) domains of specific signaling molecules and …

Phagosomes acquire their microbicidal properties by fusion with lysosomes. Products of
phosphatidylinositol 3-kinase (PI 3-kinase) are required for phagosome formation, but their role …

The temporal and geochemical evolution of arc magmatism that culminated in porphyry Cu
± Mo ± Au deposit formation has been studied in three separate Neo-Tethyan arc systems in …

Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently
in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K…