Background Cortical neuron degenerative process underlying upper motor neuron
involvement in amyotrophic lateral sclerosis (ALS) spreads to extra-motor regions as disease …

Objectives The Nigrosome-1 and putaminal hypointensity depicted on susceptibility-weighted
imaging (SWI), and midbrain atrophy assessed on T1-weighted are some of the most …

Amyotrophic lateral sclerosis (ALS) can be associated with a spectrum of cognitive and
behavioural symptoms, but the related patterns of focal cortical atrophy in non-demented ALS …

Background Behavioural changes in amyotrophic lateral sclerosis (ALS) are heterogeneous.
The study aim was to identify the behavioural profiles of non-demented patients with ALS …

Perivascular spaces (PVS) are fluid-filled compartments that dilate in response to many different
conditions. A high burden of enlarged PVS (EPVS) in the centrum semiovale (CSO) has …

Purpose The aim of the study is to quantify the susceptibility in deep grey nuclei that are
affected by pathological processes related to iron accumulation in patients with Parkinson's …

Background Huntington disease (HD) is an inherited neurodegenerative disorder most
commonly manifesting in adulthood. Identification of biomarkers tracking neurodegeneration …

Multimodal human brain mapping has been proposed as an integrated approach capable
of improving the recognition of the cortical correlates of specific neurological functions. We …

Purpose Diagnostic work-up in motor neuron disease (MND) needs a quantitative biomarker
of upper motor neuron (UMN) impairment. We investigated the susceptibility properties of …

Objectives To test whether quantitative susceptibility mapping (QSM) of cerebral cavernous
malformations (CCMs) assessed at baseline may predict the presence or absence of …