… It consists of 19 exons spanning 42 kb of genomic DNA (W Reith, B Mach, unpublished
data). Defects in the MHC2TA gene account for patients in complementation group A (Figure 2). …

… (Figure 3b; SJO and TF), (109; W Reith, J Villard, P van den Elsen, B Mach, unpublished).
The RFX5 gene is located on human chromosome 1 (W Reith, M Morris, A Gos, B Mach, …

MHC class II molecules are pivotal for the adaptive immune system, because they guide the
development and activation of CD4 + T helper cells. Fulfilling these functions requires that …

Conditional mutagenesis in mice has recently been made possible through the combination
of gene targeting techniques and site–directed mutagenesis, using the bacteriophage P1–…

Immune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, and cryopyrin
(also known as NALP3) are members of a family characterized by the presence of a NACHT …

… In this respect RFX5 behaves similarly to RFX3, which binds poorly on its own but very
efficiently as a heterodimer with RFX1 (Reith et al. 1994c). It should be mentioned, however, that …

In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of
differentiation (maturation) that exhibits specific mechanisms to control immunity. Here, we …

… The drastic effect of the W and X2 mutations also demonstrates the importance of X2BP
and W-… These factors are likely to provide direct contacts with CIITA because the X2 and W …

BACKGROUND AND PURPOSE: Data from recent reports have indicated that mechanical
thrombectomy may have potential as a treatment for acute ischemic stroke. The purpose of …

The expression of MHC class II genes is tightly regulated. One form of congenital severe
combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes …