Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153),
an apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

These practice guidelines on the management of arterial hypertension are a concise summary
of the more extensive ones prepared by the Task Force jointly appointed by the European …

Obesity‐related hypertension is increasingly recognized as a distinct hypertensive phenotype
requiring a modified approach to diagnosis and management. In this review rapidly …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

We carried out a trans-ancestry genome-wide association and replication study of blood
pressure phenotypes among up to 320,251 individuals of East Asian, European and South …

Objective To investigate functional differences between the various genotypes with respect
to basal nitric oxide (NO) production, we estimated the response to endothelial NO synthase (…

Background The distinction between unilateral aldosterone-producing adenoma or bilateral
adrenal hyperplasia as causes of primary aldosteronism is usually made by adrenal CT or …

Background and aims Bisphosphonates might be effective in reducing cardiovascular
events due to their ability to reduce calcification in arterial walls. We aimed to investigate the …

Background : Myocardial mass is a key determinant of cardiac muscle function and
hypertrophy. Myocardial depolarization leading to cardiac muscle contraction is reflected by the …