Background— Stroke is a leading cause of death and disability worldwide; however, no
effective treatment currently exists. Methods and Results— Rats receiving subcutaneous …

Background: Because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory
and neuroprotective properties and is known to mobilize stem cells, it may be useful in the …

Secretoneurin (SN), a neuropeptide derived from secretogranin II, promotes neurite outgrowth
of immature cerebellar granule cells. SN also aids in the growth and repair of neuronal …

Although stem cell-based treatments for stroke and other neurodegenerative diseases have
advanced rapidly, there are still few clinical treatments available. In this study, rats receiving …

Stem cells have two features: the ability to differentiate along different lineages and the ability
of self-renewal. Two major types of stem cells have been described, namely, embryonic …

Stromal cell-derived factor (SDF)-1α is involved in the trafficking of hematopoietic stem cells
from bone marrow to peripheral blood, and its expression is increased in the penumbra of …

The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs).
Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster …

Checkpoint immunotherapy that inhibits tumour immune evasion has demonstrated
significant clinical success. However, the therapeutic response is limited to certain patient …

Neuroplasticity subsequent to functional angiogenesis is an important goal for cell-based
therapy of ischemic neural tissues. At present, the cellular and molecular mechanisms involved …

In our previous study, intracerebral implantation of peripheral blood stem cells (PBSCs)
improved functional outcome in rats with chronic cerebral infarction. Based on this finding, a …