BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …

Background The second consensus criteria for the diagnosis of multiple system atrophy (MSA)
are widely recognized as the reference standard for clinical research, but lack sensitivity …

Mammalian genomes encode genes for more than 30 phospholipase A 2 s (PLA 2 s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast
and ovarian cancer, has been identified by positional cloning methods. Probable …

… Values on the Y and X axes represent probabilities and codon numbers, respectively.
The predicted MCC gene product is depicted in (A) and that ofthe APC gene product in (B). …

Previous studies suggested that one or more genes on chromosome 5q21 are responsible
for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), …

… and Nakamura, Y. Germ-line mutations of the APC gene in 53 familial adenomatous … and
Nakamura, Y. Allelotype of breast cancer: cumulative allele losses promote tumor progression …

A locus for familial melanoma, MLM, has been mapped within the same interval on chromosome
9p21 as the gene for a putative cell cycle regulator, p16 INK4 (CDKN2) MTS1. This …

Recent studies have suggested the existence of a tumor suppressor gene located at
chromosome region 5q21. DNA probes from this region were used to study a panel of sporadic …

Loss of heterozygosity data from familial tumors suggest that BRCA1, a gene that confers
susceptibility to ovarian and early-onset breast cancer, encodes a tumor suppressor. The …