BACKGROUND AND PURPOSE: The effects of multiple head impacts, even without
detectable primary injury, on subsequent behavioral impairment and structural abnormality …

Object. Mild, traumatic repetitive head injury (RHI) leads to neurobehavioral impairment and
is associated with the early onset of neurodegenerative disease. The authors developed an …

Mild traumatic brain injury (mTBI) or concussion is a common health issue. Several people
repeatedly experience head impact milder than that causing concussion. The present study …

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease confirmed at
postmortem. Those at highest risk are professional athletes who participate in contact sports …

Previous neuroimaging studies in rodents investigated effects of the controlled cortical
impact (CCI) model of traumatic brain injury (TBI) within one-month post-TBI. This study …

Serial MRI facilitates the in vivo analysis of the intra‐and intersubject evolution of traumatic
brain injury lesions. Despite the availability of MRI, the natural history of experimental focal …

Multiple mild traumatic brain injury (mmTBI), in certain cases, produces persistent symptoms.
However, the molecular mechanisms underlying these symptoms remain unclear. Here, we …

This study reports T2 and diffusion-tensor magnetic resonance imaging (MRI) studies of a
mild open-skull, controlled cortical impact injury in rats (n= 6) from 3 h to up to 14 d after …

The weight-drop model is used widely to replicate closed-head injuries in mice; however,
the histopathological and functional outcomes may vary significantly between laboratories …

Abstract Background and Scope of Review Varying severities and frequencies of head
trauma may result in dynamic acute and chronic pathophysiologic responses in the brain …