Primary and secondary hypertriglyceridemia is common in the general population, but the
biochemical basis for this disease is largely unknown. With the use of transgenic technology, …

Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …

Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized
by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a …

Superoxide anion can modulate vascular smooth muscle tone and potentially affect the growth
response in vascular disease. The present studies were undertaken to characterize the …

A new 2.0 ℓ DOHC 4-valve direct injection (DI) gasoline engine has been developed which
features new technologies such as swirl intake ports to produce an optimum swirl in the …

Dysfunction of microglia is known to play an important role in Alzheimer’s disease (AD). Here,
we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD. RIPK1 is …

BACKGROUND AND PURPOSE: The long-term outcome of aneurysmal coil embolization
has not been determined. We retrospectively analyzed the results of our cases treated with …

Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death:
necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way …

An ef cient and user-friendly approach is presented for constructing unstructured surface grids
directly on three-dimensional CAD surface data. This system has the following features: 1) …

This paper presents an approach to the generation of unstructured surface meshes for
Computer‐Aided Design (CAD) surface models represented as lists of polygons with minimum …