Recent studies of the northeastern part of the Tibetan Plateau have called attention to two
emerging views of how the Tibetan Plateau has grown. First, deformation in northern Tibet …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious virus
that can transmit through respiratory droplets, aerosols, or contacts. Frequent touching of …

The underlying mechanisms of wound healing are complex but inflammation is one of the
determining factors. Besides its traditional role in combating against infection upon injury, the …

Central to innate immunity is the sensing of pathogen-associated molecular patterns by cytosolic
and membrane-associated receptors 1 , 2 , 3 , 4 . In particular, DNA is a potent activator …

Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing
and anticancer effects 1 , 2 , 3 – 4 . For clinical doses of metformin, AMP-activated …

… A proportion of TNBCs have copy number gain on chromosome 6p at the E2F3 locus (ZC
Wang, unpublished data), and there is evidence for inactivation of the Rb pathway in a …

MicroRNAs are well suited to regulate tumor metastasis because of their capacity to
coordinately repress numerous target genes, thereby potentially enabling their intervention at …

Sporadic basal-like cancers (BLC) are a distinct class of human breast cancers that are
phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC …

Much interest is currently focused on the emerging role of tumor-stroma interactions essential
for supporting tumor progression. Carcinoma-associated fibroblasts (CAFs), frequently …

The activation of innate immune responses by nucleic acids is crucial to protective and
pathological immunities and is mediated by the transmembrane Toll-like receptors (TLRs) and …