Huntington's disease (HD) is a well-recognized progressive neurodegenerative disorder that
follows an autosomal dominant pattern of inheritance. Onset is insidious and can occur at …

Objectives: Huntington's disease (HD) is a profoundly incapacitating, and ultimately fatal,
neurodegenerative disease. HD is presently incurable, so the current goal is to allow …

Background Juvenile Huntington disease (JHD) is a rare clinical entity characterized by an
age at onset younger than 20 years. Patients usually have an expansion of more than 60 …

The mutation in huntingtin (mHtt) leads to a spectrum of impairments in the developing
forebrain of Huntington's disease (HD) mouse models. Whether these developmental …

Background A two-year longitudinal study composed of morphometric MRI measures and
cognitive behavioral evaluation was performed on a transgenic Huntington's disease (HD) …

Background and Objectives Brain frailty may impair the ability of acute stroke patients to
cope with the injury, irrespective of their chronologic age, resulting in impaired recovery. We …

Huntington's disease (HD) is a rare neurological disorder characterized by progressive
motor, cognitive, and psychiatric disturbances. Although striatum degeneration might justify …

BACKGROUND AND PURPOSE: Biotin-responsive basal ganglia disease is an autosomal
recessive neurometabolic disorder presenting with subacute encephalopathy that can cause …

Importance Age is a leading predictor of poor outcomes after brain injuries like stroke. The
extent to which age is associated with preexisting burdens of brain changes, visible on …

Global brain atrophy was determined in 70 patients suffering from Huntington's disease (HD)
and 70 healthy controls, using brain parenchymal fractions calculated from 3D MRI data in a …