The development of magnetic resonance imaging (MRI) for use in medical investigation has
provided a huge forward leap in the field of diagnosis, particularly with avoidance of …

Until the advent of MR imaging, knowledge of the structure of myelin and the process of
myelination were of little importance to the neuroradiologist. Other than some mild changes …

Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …

The apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for Alzheimer's
disease (AD). APOE4 carriers develop systemic metabolic dysfunction decades before …

Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration,. The
neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1), is permeable to …

In vivo exploration of activated microglia in neurodegenerative diseases is achievable by
Positron Emission Tomography (PET) imaging, using dedicated radiopharmaceuticals …

Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …

Since its technical development in the early 1980s, magnetic resonance imaging (MRI) has
quickly been adopted as an essential tool in supporting the diagnosis, longitudinal …

Magnetic resonance (MR) spectroscopy is an analytical method used in chemistry that
enables the identification and quantification of metabolites in samples. It differs from …

The measurement of brain metabolites with magnetic resonance spectroscopy (MRS)
provides a unique perspective on the brain bases of neuropsychiatric disorders. As a context …