Recent work continues to place cholinergic circuits at center stage for normal executive and
mnemonic functioning and provides compelling evidence that the loss of cholinergic …

In the long-term, with progression of the illness, Parkinson's disease dementia affects up to
90% of patients with Parkinson's disease. With increasing life expectancy in western …

Dementia affects about 40% of patients with Parkinson's disease; the incidence of dementia
in these patients is up to six times that in healthy people. Clinically, the prototype of …

Within the last years, a rapidly growing number of polyphenolic compounds with
neuroprotective effects have been described. Many efforts have been made to explore the …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …

BACKGROUND: The basal forebrain cholinergic system (BFCS) is known to undergo
moderate neurodegenerative changes during normal aging as well as severe atrophy in …

The basal forebrain contains several interdigitating anatomical structures, including the
diagonal band of Broca, the basal nucleus of Meynert, the ventral striatum, and also cell …

The frontal and temporal lobe regions of the brain have a high vulnerability to injury as a
consequence of cerebral trauma. One reason for this selective vulnerability is how the frontal …

Mild cognitive impairment (MCI) is rapidly becoming one of the most common clinical
manifestations affecting the elderly. The pathologic and molecular substrate of people …

The central cholinergic system includes the basal forebrain nuclei, mainly projecting to the
cortex, the mesopontine tegmental nuclei, mainly projecting to the thalamus and subcortical …