Batten disease (also known as neuronal ceroid lipofuscinoses) constitutes a family of
devastating lysosomal storage disorders that collectively represent the most common …

Late infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive,
neurodegenerative lysosomal storage disease affecting the CNS and is fatal by age 8 to 12 …

Neuronal ceroid lipofuscinoses (NCLs) are a heterogeneous group of lysosomal storage
disorders. NCLs include the rare autosomal recessive neurodegenerative disorder neuronal …

Object The authors conducted a phase I study of late infantile neuronal ceroid lipofuscinosis
using an adenoassociated virus serotype 2 (AAV2) vector containing the deficient CLN2 …

BACKGROUND AND PURPOSE: Experimental therapies for ceroid lipofuscinosis, neuronal,
2 (CLN2), a genetic disorder of childhood associated with progressive brain atrophy, are …

BACKGROUND AND PURPOSE: Accurate diagnosis of normal pressure hydrocephalus is
challenging because the clinical symptoms and radiographic appearance of NPH often …

Objective: To use arterial spin labeling (ASL) to compare cerebral blood flow (CBF) patterns
in minimally conscious state (MCS) patients with those in normal controls in an …

BACKGROUND AND PURPOSE: Normal values of gray matter volume, cerebral blood flow,
and water diffusion have not been established for healthy children. We sought to determine …

ABSTRACT BACKGROUND AND PURPOSE Data about the predictive value of quantitative
diffusion‐weighted MRI in traumatic brain injury (TBI) patients is lacking. This study aimed to …

BACKGROUND AND PURPOSE: LINCL is a uniformly fatal lysosomal storage disease
resulting from mutations in the CLN2 gene that encodes for tripeptidyl peptidase 1, a …