Iron overload and iron toxicity, whether because of increased absorption or iron loading from
repeated transfusions, can be major causes of morbidity and mortality in a number of chronic …

Both primary and secondary iron overload are increasingly prevalent in the United States
because of immigration from the Far East, increasing transfusion therapy in sickle cell …

Iron overload is becoming an increasing problem as haemoglobinopathy patients gain
greater access to good medical care and as therapies for myelodysplastic syndromes …

In ancient Greece, iron was thought to be imparted from the mythological figure Mars and
therefore associated with “force” and “strength.” 1, 2 It was thus primarily used …

Thus a patient receiving 150 mL/kg/y of PRBCs having an Hct of 70% would increase the
liver iron by 10 mg/g in the absence of iron chelation. As a rule of thumb, each 15 mL/kg …

Chronic blood transfusions start at a very young age in subjects with transfusion‐dependent
anemias, the majority of whom have hereditary anemias. To understand how rapidly iron …

Abstract Changes in thyroid function and thyroid function tests occur in patients with β-
thalassemia major (TM). The frequency of hypothyroidism in TM patients ranges from 4% to …

Juvenile haemochromatosis is a severe inherited iron-loading disorder that can present in
children and adolescents. Typical manifestations include heart failure, endocrine failure …

Long-term survival of patients with transfusion-dependent thalassemia (TDT) raises hopes of
attaining a decent quality of life, having a family and maintaining reproductive potential …

Background The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely
investigated in mood disorders based on its role in regulating stress response. Particularly …