Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

R Leigh, L Knutsson, J Zhou… - Journal of Cerebral …, 2018 - journals.sagepub.com
We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …

[HTML][HTML] Mini review: circular RNAs as potential clinical biomarkers for disorders in the central nervous system

D Lu, AD Xu - Frontiers in genetics, 2016 - frontiersin.org
Circular RNAs (circRNAs) are a type of non-coding RNAs (ncRNAs), produced in eukaryotic
cells during post-transcriptional processes. They are more stable than linear RNAs, and …

Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease

JT Grist, JJ Miller, F Zaccagna… - Journal of Cerebral …, 2020 - journals.sagepub.com
Cerebral metabolism is tightly regulated and fundamental for healthy neurological function.
There is increasing evidence that alterations in this metabolism may be a precursor and …

Quantitative sodium MR imaging: A review of its evolving role in medicine

KR Thulborn - Neuroimage, 2018 - Elsevier
Sodium magnetic resonance (MR) imaging in humans has promised metabolic information
that can improve medical management in important diseases. This technology has yet to find …

[HTML][HTML] Aerobic training and mobilization early post-stroke: cautions and considerations

S Marzolini, AD Robertson, P Oh, JM Goodman… - Frontiers in …, 2019 - frontiersin.org
Knowledge gaps exist in how we implement aerobic exercise programs during the early
phases post-stroke. Therefore, the objective of this review was to provide evidence-based …

X‐nuclei imaging: Current state, technical challenges, and future directions

R Hu, D Kleimaier, M Malzacher… - Journal of Magnetic …, 2020 - Wiley Online Library
1H imaging is concerned with contrast generation among anatomically distinct soft tissues. X‐
nuclei imaging, on the other hand, aims to reveal the underlying changes in the …

Fast high-resolution metabolic imaging of acute stroke with 3D magnetic resonance spectroscopy

Y Li, T Wang, T Zhang, Z Lin, Y Li, R Guo, Y Zhao… - Brain, 2020 - academic.oup.com
Impaired oxygen and cellular metabolism is a hallmark of ischaemic injury in acute stroke.
Magnetic resonance spectroscopic imaging (MRSI) has long been recognized as a …

Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities

SK Sanganalmath, P Gopal, JR Parker… - Molecular and cellular …, 2017 - Springer
Circulatory arrest (CA) remains a major unresolved public health problem in the United
States; the annual incidence of which is~ 0.50 to 0.55 per 1000 population. Despite seminal …

Refined ischemic penumbra imaging with tissue pH and diffusion kurtosis magnetic resonance imaging

J Cheung, M Doerr, R Hu, PZ Sun - Translational stroke research, 2021 - Springer
Imaging has played a vital role in our mechanistic understanding of acute ischemia and the
management of acute stroke patients. The most recent DAWN and DEFUSE-3 trials showed …

[HTML][HTML] Imaging acute stroke: from one-size-fit-all to biomarkers

J Lu, Q Mei, X Hou, A Manaenko, L Zhou… - Frontiers in …, 2021 - frontiersin.org
In acute stroke management, time window has been rigidly used as a guide for decades and
the reperfusion treatment is only available in the first few limited hours. Recently, imaging …