More than 50 monoclonal antibodies (mAbs), including several antibody–drug conjugates,
are in advanced clinical development, forming an important part of the many molecularly …

Introduction: Single photon emission computed tomography (SPECT) with Ioflupane I123
injection (DaTscan™) was approved by the Food and Drug Administration in 2011 for striatal …

Autopsy-validated studies of clinical diagnostic accuracy in early Parkinson's disease (PD)
indicate that, as compared with patients followed for a number of years, misdiagnosis is …

Early and accurate identification of Parkinsonian syndromes (PS) involving presynaptic
degeneration from nondegenerative variants such as scans without evidence of …

Finding new biomarkers to model Parkinson's Disease (PD) is a challenge not only to help
discerning between Healthy Control (HC) subjects and patients with potential PD but also as …

Objective The objective of this study was to identify the extent to which artificial intelligence
could be used in the diagnosis of Parkinson's disease from ioflupane-123 (123 I) single …

Early detection of Parkinson's disease (PD) is very crucial for effective management and
treatment of the disease. Dopaminergic images such as Single Photon Emission …

Background We hypothesised that the radiomics signature, which includes texture
information of dopamine transporter single-photon emission computed tomography (DAT …

Background Clinical estimates of brain iron concentration are achievable with quantitative
transverse relaxation rate R 2, via time-consuming multiple spin-echo (SE) sequences. The …

Corticobasal degeneration (CBD) is a neurodegenerative condition characterized by 4R tau
protein deposition in several brain regions that clinically manifests itself as a heterogeneous …