Purpose To evaluate the predictors of and time taken for the translation of highly promising
basic research into clinical experimentation and use. Methods We identified 101 articles …

The most efficient drugs to alleviate severe pain are opioid compounds. However, their
chronic use could be associated with serious drawbacks, such as tolerance, respiratory …

We have isolated a cDNA clone encoding human enkephalinase (neutral endopeptidase,
EC 3.4. 24.11) in a λgt10 library from human placenta, and present the complete 742 amino …

cDNA clones encoding rat enkephalinase (neutral endopeptidase, EC 3.4. 24.11) have
been isolated in λgt10 libraries from both brain and kidney mRNAs and the complete 742 …

The dual enkephalinase inhibitor PL37, a small molecule that protects enkephalins from
rapid degradation, has demonstrated analgesic properties in animal pain models and in …

The presence of the neutral metallo-endopeptidase 3.4. 24.11 (“enkephalinase”) activity was
investigated by fluorimetric assay in human body fluids. Although the enzyme was …

Background We have recently shown that treatment of mice with the neutral endopeptidase
(NEP) inhibitor phosphoramidon (PA) improves the bioavailability and tumor uptake of …

The metallopeptidase enkephalinase known to participate in the inactivation of endogenous
enkephalins and, possibly, other neuropeptides such as tachykinins, was visualized by …

The discovery of endogenous opioids has begun an intricate saga involving multiple ligands
and multiple receptors that form an extensive neuronal network in both the central and …

Thiorphan, the potent inhibitor of 'enkephalinase', has shown some analgesic properties in
experimental animals and in man. The possibility that the intravenous infusion of …