The hypermobile type of Ehlers–Danlos syndrome (hEDS) is likely the most common
hereditary disorder of connective tissue. It has been described largely in those with …

Loeys–Dietz syndrome is a connective tissue disorder predisposing individuals to aortic and
arterial aneurysms. Presenting with a wide spectrum of multisystem involvement, medical …

Spontaneous intracranial artery dissection is an uncommon and probably underdiagnosed
cause of stroke that is defined by the occurrence of a haematoma in the wall of an …

The sites and patterns of tortuosity are dependent on key anatomic factors. These include:•
Anatomic fixation—vascular elongation between 2 fixed points will give rise to tortuosity. 16 …

Intracranial aneurysms (IA) are local dilatations in cerebral arteries that predominantly affect
the circle of Willis. Occurring in approximately 2–5% of adults, these weakened areas are …

Abstract Introduction Loeys-Dietz syndrome (LDS) is a connective tissue disorder that arises
from mutations altering the transforming growth factor β signalling pathway. Due to the …

Background—Arterial tortuosity is described as a common and distinctive feature of Loeys-
Dietz syndrome (LDS), yet reports on arterial tortuosity are based on qualitative observations …

Large cohorts of CeAD patients have refined our understanding of the pathophysiology and
risk factors of CeAD, but the molecular mechanisms are still poorly understood. Ongoing …

Intracranial artery dissections (IAD) are uncommon entities associated with high rates of
morbidity and mortality. Certain ethnic groups and patients with underlying connective tissue …

Loeys-Dietz syndrome is an autosomal dominant aortic aneurysm syndrome characterized
by multisystemic involvement. The most typical clinical triad includes hypertelorism, bifid …