When the language-dominant hemisphere is damaged by a focal lesion, the brain may
reorganize the language network through functional and structural changes known as adaptive …

Functional magnetic resonance imaging (fMRI) has been adopted almost universally by
disciplines that endeavor to understand how the brain works. As basic scientists tune the …

Erlotinib is effective for epidermal growth factor receptor (EGFR) mutant lung cancer, but
CNS penetration at standard daily dosing is limited. We previously reported that intermittent “…

BACKGROUND AND PURPOSE: Functional MR (fMR) imaging data coregistered to a
neurosurgical navigation system have been proposed as guides for the resection of brain tumor in …

Brain tumor resection is an integral part of the treatment of patients with brain tumors, as most
outcomes are believed to improve after gross total resection (a notable exception is central …

Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize
energy metabolism in the human brain and brain tumors. Here, we present the first dynamically …

… Holodny has served on a scientific advisory board for Bayer Schering Pharma and serves
on the editorial advisory board of the American Journal of Neuroradiology. Dr. Omuro served …

… AI Holodny, unpublished data). However, because the motor cortex is a gyrus and not a point,
these potential sources oferror have not proved to be significant in this series. Registration …

… All imaging studies were reviewed by independent radiologists (AI Holodny and MS
Ginsberg). An internal radiological review of randomly selected patients was conducted by the …

Background The majority of WHO grades II and III gliomas harbor a missense mutation in
the metabolic gene isocitrate dehydrogenase (IDH) and accumulate the metabolite R-2-…