Unlocking G-quadruplexes as antiviral targets
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …
[HTML][HTML] Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer–contradictory effects and future …
…, MA Khoshkbejari, M Mohammadi, A Abiri… - Biomedicine & …, 2020 - Elsevier
Breast cancer is the most common type of cancer among women. Therefore, discovery of new
and effective drugs with fewer side effects is necessary to treat it. Sulforaphane (SFN) is an …
and effective drugs with fewer side effects is necessary to treat it. Sulforaphane (SFN) is an …
Where ferroptosis inhibitors and paraquat detoxification mechanisms intersect, exploring possible treatment strategies
…, M Mohit, J Salehi, M Ashrafizadeh, A Najafi, A Abiri - Toxicology, 2020 - Elsevier
Paraquat (PQ) is a fast-acting and effective herbicide that is used throughout the world to
eliminate weeds. Over the past years, PQ was considered one of the most popular poisoning …
eliminate weeds. Over the past years, PQ was considered one of the most popular poisoning …
[HTML][HTML] Brain-computer interface controlled functional electrical stimulation system for ankle movement
Background Many neurological conditions, such as stroke, spinal cord injury, and traumatic
brain injury, can cause chronic gait function impairment due to foot-drop. Current …
brain injury, can cause chronic gait function impairment due to foot-drop. Current …
[HTML][HTML] Multi-modal haptic feedback for grip force reduction in robotic surgery
Minimally invasive robotic surgery allows for many advantages over traditional surgical
procedures, but the loss of force feedback combined with a potential for strong grasping forces …
procedures, but the loss of force feedback combined with a potential for strong grasping forces …
Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study
Background Despite the large number of pregnant women with the coronavirus disease
2019 (COVID-19), there is not enough analytical study to compare maternal and fetal …
2019 (COVID-19), there is not enough analytical study to compare maternal and fetal …
Exploring the out of sight antigens of SARS-CoV-2 to design a candidate multi-epitope vaccine by utilizing immunoinformatics approaches
SARS-CoV-2 causes a severe respiratory disease called COVID-19. Currently, global health
is facing its devastating outbreak. However, there is no vaccine available against this virus …
is facing its devastating outbreak. However, there is no vaccine available against this virus …
In silico analysis of transmembrane protein 31 (TMEM31) antigen to design novel multiepitope peptide and DNA cancer vaccines against melanoma
Multiepitope cancer vaccines are announcing themselves as the future of melanoma
treatment. Herein, high immunogenic regions of transmembrane protein 31 (TMEM31) antigen …
treatment. Herein, high immunogenic regions of transmembrane protein 31 (TMEM31) antigen …
[HTML][HTML] Phenoxyethyl piperidine/morpholine derivatives as PAS and CAS inhibitors of cholinesterases: insights for future drug design
Acetylcholinesterase (AChE) catalyzes the conversion of Aβ peptide to its aggregated form
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …
and the peripheral anionic site (PAS) of AChE is mainly involved in this phenomenon. Also …
Soft iontronic capacitive sensor for beat‐to‐beat blood pressure measurements
Continuous beat‐to‐beat blood pressure (BP) monitoring provides hemodynamic information
such as BP changes and waveforms over time, providing abundant information to more …
such as BP changes and waveforms over time, providing abundant information to more …