Over the past few years, a wealth of biochemical and functional data has been gathered on
mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases …

The aim of this review is to evaluate long-term follow-up and survival analysis studies regarding
high tibial osteotomies (HTO) for the treatment of medial knee arthritis. Despite the good …

Ankle sprains are among the most common athletic injuries and represent a significant source
of persistent pain and disability. Despite the high incidence of ankle sprains in athletes, …

Calcium release from the endoplasmic reticulum controls a number of cellular processes,
including proliferation and contraction of smooth muscle and other cells 1 , 2 . Calcium release …

Cyclic GMP-dependent protein kinase I (cGKI) affects the inositol 1,4,5-trisphosphate (InsP
3 )-dependent release of intracellular calcium by phosphorylation of IRAG (inositol 1,4,5-…

Background & Aims No established therapies for patients with hepatocellular carcinoma (HCC)
and progression on first-line sorafenib treatment currently exist. This phase I/II trial …

Introduction Several recent case reports have described common early chest imaging findings
of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be …

Background: The purpose of this study was to compare a custom-made valgus-producing
functional knee (unloader) brace, a neoprene sleeve, and medical treatment only (control …

Background: Vidofludimus (SC12267) is a novel oral immunomodulator inhibiting dihydroorotate
dehydrogenase (DHODH) and the expression of proinflammatory cytokines including …

The purpose of our study was to identify the cause of symptomatic ankle arthritis in a
consecutive series of patients presenting in a tertiary care setting. Between 1991 and 2004, 639 …