MiR-125 is a highly conserved microRNA throughout many different species from nematode
to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa…

RNA interference (RNAi) represents an evolutionarily conserved cellular defense for controlling
the expression of foreign genes in most eukaryotes including humans. RNAi is triggered …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes and …

Pan-cancer analyses that examine commonalities and differences among various cancer
types have emerged as a powerful way to obtain novel insights into cancer biology. Here we …

MicroRNAs (miRNAs) represent a new class of noncoding RNAs encoded in the genomes of
plants, invertebrates, and vertebrates. MicroRNAs regulate translation and stability of target …

Epidemiological evidence has suggested that some pediatric leukemias may be initiated in
utero and, for some pairs of identical twins with concordant leukemia, this possibility has …

Purpose Blinatumomab is a bispecific T-cell engager antibody construct targeting CD19 on
B-cell lymphoblasts. We evaluated the safety, pharmacokinetics, recommended dosage, and …

Epigenetic alterations, that is, disruption of DNA methylation and chromatin architecture, are
now acknowledged as a universal feature of tumorigenesis 1 . Medulloblastoma, a clinically …

To define prognostic factors in infant acute lymphoblastic leukemia (ALL), the outcome of
106 infants (age ≤12 months) during 3 consecutive multicenter trials of the Berlin-Frankfurt-…

Background Children with Down's syndrome have a greatly increased risk of acute
megakaryoblastic and acute lymphoblastic leukaemias. Acute megakaryoblastic leukaemia in …