Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Opioid treatment of pain is generally safe with 0.5% or less events from respiratory depression.
However, fatalities are regularly reported. The only treatment currently available to …

As a consequence of modern drug discovery techniques, there has been a consistent
increase in the number of new pharmacologically active lipophilic compounds that are poorly …

▪ Abstract Summary of consensus: 1. The use of opioids in cancer pain: The criteria for selecting
analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy…

Background. We measured the effect of two weight adjusted iv doses (0.2 mg per 70 kg and
0.4 mg per 70 kg) of the potent opioid buprenorphine on analgesia and respiratory …

Background Animal and human studies indicate the existence of important sex-related
differences in opioid-mediated behavior. In this study the authors examined the influence of …

Background. There is evidence from animal studies suggesting the existence of a ceiling effect
for buprenorphine-induced respiratory depression. To study whether an apparent ceiling …

Complex Regional Pain Syndrome Type 1 (CRPS-1) responds poorly to standard pain
treatment. We evaluated if the N-methyl-d-aspartate receptor antagonist S(+)-ketamine improves …

Despite the increasing clinical use of transdermal buprenorphine, questions have persisted
about the possibility of a ceiling effect for analgesia, its combination with other μ‐opioid …

The anaesthetic ketamine is used to treat various chronic pain syndromes, especially those
that have a neuropathic component. Low dose ketamine produces strong analgesia in …