Glioblastomas (GBMs) are very aggressive tumors that are resistant to conventional chemo-
and radiotherapy. New molecular therapeutic strategies are required to effectively eliminate …

The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating
cells, but successful metastases bypass this control through mechanisms that are …

Background: Glioblastoma (GBM) is one of the most lethal tumor types. Hypercellular regions,
named pseudopalisades, are characteristic in these tumors and have been hypothesized …

Glioblastomas (GBM) are devastating tumors in which there has been little clinical improvement
in the last decades. New molecularly directed therapies are under development. EGFR …

Gliomas that express the mutated isoforms of isocitrate dehydrogenase 1/2 (IDH1/2) have
better prognosis than wild-type (wt) IDH1/2 gliomas. However, how these mutant (mut) …

Background We conducted a multicenter, 2-stage, open-label, phase II trial to assess the
efficacy and safety of dacomitinib in adult patients with recurrent glioblastoma (GB) and …

This study identifies the EGFR-related mechanisms that govern the capacity of glioma cells
to transdifferentiate into pericytes, regulating the vascular and immune phenotypes of the …

Whole-brain radiotherapy (WBRT) is the treatment backbone for many patients with brain
metastasis; however, its efficacy in preventing disease progression and the associated toxicity …

Diffuse infiltrating low-grade gliomas include oligodendrogliomas and astrocytomas, and
account for about 5% of all primary brain tumors. Treatment strategies for these low-grade …

Oligodendroglial tumors (OTs) are primary brain tumors that show variable clinical and
biological behavior. The 1p/19q codeletion is frequent in these tumors, indicating a better …