Leptin, a peptide secreted from adipose tissue, plays an important role in the regulation of
food intake and energy expenditure. In obese patients, plasma leptin levels are elevated and …

Chrysanthemum (Chrysanthemum morifolium) is a short-day plant, which flowers when the
night length is longer than a critical minimum. Flowering is effectively inhibited when the …

Thrombopoietin is known to be essential for megakaryocytopoiesis and thrombopoiesis.
Recently, we and others have shown that thrombopoietin induces rapid tyrosine …

The non‐transmembrane phosphotyrosine phosphatase 1B (PTP‐1B) is an abundant
enzyme, normally localized to the cytosolic face of the endoplasmic reticulum via a C‐terminal …

The floral regulators GIGANTEA (GI), CONSTANS (CO), and FLOWERING LOCUS T (FT)
play key roles in the photoperiodic flowering responses of the long-day plant Arabidopsis …

WAVE2 activates the actin-related protein (Arp) 2/3 complex for Rac-induced actin polymerization
during lamellipodium formation and exists as a large WAVE2 protein complex with …

Here, the comparisons of performance of nine consensus scoring strategies, in which multiple
scoring functions were used simultaneously to evaluate candidate structures for a protein−…

Background Multiple myeloma (MM) expands almost exclusively in the bone marrow and
generates devastating bone lesions, in which bone formation is impaired and osteoclastic …

Identifying the mechanisms through which genetic risk causes dementia is an imperative for
new therapeutic development. Here, we apply a multistage, systems biology approach to …

Cancer cells eventually acquire drug resistance largely via the aberrant expression of ATP-binding
cassette (ABC) transporters, ATP-dependent efflux pumps. Because cancer cells …