User profiles for A. Pikula

Aleksandra Pikula

Associate Professor of Medicine(Neurology) - University of Toronto
Verified email at uhn.ca
Cited by 4982

Cerebral collateral circulation in carotid artery disease

JR Romero, A Pikula, TN Nguyen… - Current cardiology …, 2009 - ingentaconnect.com
Carotid artery disease is common and increases the risk of stroke. However, there is wide
variability on the severity of clinical manifestations of carotid disease, ranging from …

Stroke prevention: modifying risk factors

JR Romero, J Morris, A Pikula - Therapeutic advances in …, 2008 - journals.sagepub.com
Risk factor modification remains as the principal aspect of care for stroke prevention.
Understanding of risk factors has advanced and several options are now available to treat …

Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial

…, AR Luft, M Piotin, JC Gentric, A Pikula… - The Lancet, 2022 - thelancet.com
Background Whether thrombectomy alone is equally as effective as intravenous alteplase
plus thrombectomy remains controversial. We aimed to determine whether thrombectomy …

Red blood cell omega-3 fatty acid levels and markers of accelerated brain aging

…, AS Beiser, R Au, JJ Himali, S Debette, A Pikula… - Neurology, 2012 - AAN Enterprises
Objective: Higher dietary intake and circulating levels of docosahexaenoic acid (DHA) and
eicosapentaenoic acid (EPA) have been related to a reduced risk for dementia, but the …

Serum brain-derived neurotrophic factor and the risk for dementia: the Framingham Heart Study

…, SR Preis, TC Chen, D Vorgas, R Au, A Pikula… - JAMA …, 2014 - jamanetwork.com
Importance In animal studies, brain-derived neurotrophic factor (BDNF) has been shown to
impact neuronal survival and function and improve synaptic plasticity and long-term memory. …

Parental occurrence of stroke and risk of stroke in their children: the Framingham study

S Seshadri, A Beiser, A Pikula, JJ Himali… - Circulation, 2010 - Am Heart Assoc
Background— Data relating parental history of stroke to stroke risk in offspring remain
surprisingly inconsistent, largely because of heterogeneity of study design and the absence of …

Insulin-like growth factor-1 and risk of Alzheimer dementia and brain atrophy

…, TB Harris, TC Chen, X He, R Roubenoff, A Pikula… - Neurology, 2014 - AAN Enterprises
Objective: To relate serum insulin-like growth factor-1 (IGF-1) to risk of Alzheimer disease (AD)
dementia and to brain volumes in a dementia-free community sample spanning middle …

Endovascular management of acute stroke in the elderly: a systematic review and meta-analysis

…, A Rabinstein, J Schaafsma, A Pikula… - American Journal …, 2018 - Am Soc Neuroradiology
Background: Acute ischemic stroke occurs more frequently, presents with more severe
symptoms, and has worse outcomes in elderly patients. The safety and efficacy of endovascular …

Serum brain–derived neurotrophic factor and vascular endothelial growth factor levels are associated with risk of stroke and vascular brain injury: Framingham study

A Pikula, AS Beiser, TC Chen, SR Preis, D Vorgias… - Stroke, 2013 - Am Heart Assoc
Background and Purpose— Brain-derived neurotrophic factor (BDNF), a major neurotrophin
and vascular endothelial growth factor (VEGF) have a documented role in neurogenesis, …

Identification of senescence-associated genes from daylily petals

T Panavas, A Pikula, PD Reid, B Rubinstein… - Plant Molecular …, 1999 - Springer
The petals of daylily (Hemerocallis hybrid) have a genetically based program that leads to
senescence and cell death ca. 24 h after the flower opens. In order to determine the …