The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Estrogen receptors are broadly expressed in many cell types involved in the innate and
adaptive immune responses, and differentially regulate the production of cytokines. While both …

Lung cancer is the deadliest malignancy with more cancer deaths per year than the next
three cancers combined. Despite remarkable advances in targeted therapy, advanced lung …

In this paper we introduce the concepts of domination and total domination in fuzzy graphs.
We determine the domination number γ and the total domination number γ t for several …

Two defining functional features of ion channels are ion selectivity and channel gating. Ion
selectivity is generally considered an immutable property of the open channel structure, …

Xanthine oxidase inhibitory activity was assayed from six species belonging to different
families traditionally used for the treatment of gout and related symptoms by indigenous people …

Rationale: There is an urgent need for improved understanding of the mechanisms and clinical
characteristics of acute respiratory distress syndrome (ARDS) due to coronavirus disease …

Ca 2+ entry through store‐operated Ca 2+ release‐activated Ca 2+ (CRAC) channels
initiates key functions such as gene expression and exocytosis of inflammatory mediators. …

Calcium signals regulate many critical processes during vertebrate brain development
including neurogenesis, neurotransmitter specification, and axonal outgrowth. However, the …

Key points • The endoplasmic reticulum protein, stromal interaction molecule 1 (STIM1),
activates Orai1 channels by directly interacting with each Orai1 subunit at the C‐ and N‐termini. …